Which condition is a known association with Congenital Diaphragmatic Hernia (CDH)?

Which condition is a known association with Congenital Diaphragmatic Hernia (CDH)?

• A. Trisomy 21
• B. Trisomy 18
• C. Turner Syndrome
• D. Cleidocranial Dysostosis

Answer: (B)

Congenital Diaphragmatic Hernia (CDH) is a condition where there is a defect in the diaphragm that allows abdominal contents to move into the thoracic cavity, which can severely affect lung development. Trisomy 18, also known as Edwards syndrome, is one of the chromosomal abnormalities that has a known association with CDH. The presence of CDH in infants with Trisomy 18 can be part of a spectrum of anomalies that arise due to the chromosomal defect. Trisomy 18 is characterized by multiple congenital anomalies, and CDH is among the structural heart and thoracic issues seen in these infants. This association is clinically significant, as it can help inform the management and potential outcomes for affected infants. In contrast, while other conditions like Trisomy 21, Turner Syndrome, and Cleidocranial Dysostosis have their own associations with various congenital anomalies, they are not specifically known to have a strong association with CDH in the same way that Trisomy 18 does. Understanding the chromosomal contexts in which congenital conditions occur is crucial for predicting clinical outcomes and managing these patients effectively.

Congenital Diaphragmatic Hernia (CDH) is a condition where there is a defect in the diaphragm that allows abdominal contents to move into the thoracic cavity, which can severely affect lung development. Trisomy 18, also known as Edwards syndrome, is one of the chromosomal abnormalities that has a known association with CDH.

The presence of CDH in infants with Trisomy 18 can be part of a spectrum of anomalies that arise due to the chromosomal defect. Trisomy 18 is characterized by multiple congenital anomalies, and CDH is among the structural heart and thoracic issues seen in these infants. This association is clinically significant, as it can help inform the management and potential outcomes for affected infants.

In contrast, while other conditions like Trisomy 21, Turner Syndrome, and Cleidocranial Dysostosis have their own associations with various congenital anomalies, they are not specifically known to have a strong association with CDH in the same way that Trisomy 18 does. Understanding the chromosomal contexts in which congenital conditions occur is crucial for predicting clinical outcomes and managing these patients effectively.